Tsai P*, Lee M*, Jadhav U, Naqvi I, Madha S, Adler A, Mistry M, Lewis CA, Hitchcock DS, Roberts FR, DelNero P, Hank T, Honselmann KC, Morales Oyarvide V, Mino-Kenudson M, Clish CB, Shivdasani RA, Kalaany NY. Adaptation of pancreatic cancer cells to nutrinet deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. bioRxiv 2020. Revised Nov 14; doi: 10.1101/2020.02.16.951681
* equal authorship
* equal authorship
Xu H*, Lee MS*, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY. Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis. PNAS 2018. Apr 17;115(16):4228-4233.
* equal authorship
* equal authorship
Zaytouni, T, Tsai, P-Y, Hitchcock, DS, DuBois, CD, Freinkman, E, Lin, L, Morales-Oyarvide, V, Lenehan, PJ, Wolpin, BM, Mino-Kenudson, M, Torres, EM, Stylopoulos, N, Clish, CB, and Kalaany, NY. Critical role for arginase 2 and the urea cycle in obesity-associated pancreatic cancer. Nat Commun 2017. Aug 14;8(1):242.
Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun 2017. Jan 10;8:13989.
Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov 2014. Aug;4(8):914-927.
Curry, N.L., Mino-Kenudson, M., Oliver, T.G., Yilmaz, O.H., Yilmaz, V.O., Moon, J.Y., Jacks, T., Sabatini, D.M., and Kalaany, N.Y. Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. Cancer Discov 2013 Aug;3(8):908-921.
Possemato, R., Marks, K.M., Shaul, Y.D., Pacold, M.E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.K., Jang, H.G., Jha, A.K., Chen, W.W., Barrett, F.G., Stransky, N., Tsun, Z.Y., Cowley, G.S., Barretina, J., Kalaany, N.Y., Hsu, P.P., Ottina, K., Chan, A.M., Yuan, B., Garraway, L.A., Root, D.E., Mino-Kenudson, M., Brachtel, E.F., Driggers, E.M., and Sabatini, D.M. Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer. Nature 2011 Aug 18;476(7360):346-350.
Kalaany, N.Y., and Sabatini, D.M. Tumours with PI3K activation are resistant to dietary restriction. Nature 2009 Apr 9;458(7239):725-731.
Kalaany, N.Y., and Mangelsdorf, D.J. LXRs and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 2006;68:159-191. Review.
Kalaany, N.Y., Gauthier, K.C., Zavacki, AM, Mammen, P.P., Kitazume, T., Peterson, J.A., Horton, J.D., Garry, D.J., Bianco, A.C., and Mangelsdorf, D.J. LXRs regulate the balance between fat storage and oxidation. Cell Metab 2005 Apr;1(4):231-244.